Integrated Information in the Spiking-Bursting Stochastic Model

This study presents a comprehensive analytic description in terms of the empirical "whole minus sum" version of Integrated Information in comparison to the "decoder based" version for the "spiking-bursting" discrete-time, discrete-state stochastic model, which was recently introduced to describe a specific type of dynamics in a neuron-astrocyte network. The "whole minus sum" information may change sign, and an interpretation of this transition in terms of "net synergy" is available in the literature. This motivates our particular interest to the sign of the "whole minus sum" information in our analytical consideration. The behavior of the "whole minus sum" and "decoder based" information measures are found to bear a lot of similarity, showing their mutual asymptotic convergence as time-uncorrelated activity is increased, with the sign transition of the "whole minus sum" information associated to a rapid growth in the "decoder based" information. The study aims at creating a theoretical base for using the spiking-bursting model as a well understood reference point for applying Integrated Information concepts to systems exhibiting similar bursting behavior (in particular, to neuron-astrocyte networks). The model can also be of interest as a new discrete-state test bench for different formulations of Integrated Information

Distributed classifier based on genetically engineered bacterial cell cultures

We describe a conceptual design of a distributed classifier formed by a population of genetically engineered microbial cells. The central idea is to create a complex classifier from a population of weak or simple classifiers. We create a master population of cells with randomized synthetic biosensor circuits that have a broad range of sensitivities towards chemical signals of interest that form the input vectors subject to classification. The randomized sensitivities are achieved by constructing a library of synthetic gene circuits with randomized control sequences (e.g. ribosome-binding sites) in the front element. The training procedure consists in re-shaping of the master population in such a way that it collectively responds to the "positive" patterns of input signals by producing above-threshold output (e.g. fluorescent signal), and below-threshold output in case of the "negative" patterns. The population re-shaping is achieved by presenting sequential examples and pruning the population using either graded selection/counterselection or by fluorescence-activated cell sorting (FACS). We demonstrate the feasibility of experimental implementation of such system computationally using a realistic model of the synthetic sensing gene circuits.Comment: 31 pages, 9 figure

Multi-input distributed classifiers for synthetic genetic circuits

For practical construction of complex synthetic genetic networks able to perform elaborate functions it is important to have a pool of relatively simple "bio-bricks" with different functionality which can be compounded together. To complement engineering of very different existing synthetic genetic devices such as switches, oscillators or logical gates, we propose and develop here a design of synthetic multiple input distributed classifier with learning ability. Proposed classifier will be able to separate multi-input data, which are inseparable for single input classifiers. Additionally, the data classes could potentially occupy the area of any shape in the space of inputs. We study two approaches to classification, including hard and soft classification and confirm the schemes of genetic networks by analytical and numerical results

Brain aging and garbage cleaning : Modelling the role of sleep, glymphatic system, and microglia senescence in the propagation of inflammaging

Brain aging is a complex process involving many functions of our body and described by the interplay of a sleep pattern and changes in the metabolic waste concentration regulated by the microglial function and the glymphatic system. We review the existing modelling approaches to this topic and derive a novel mathematical model to describe the crosstalk between these components within the conceptual framework of inflammaging. Analysis of the model gives insight into the dynamics of garbage concentration and linked microglial senescence process resulting from a normal or disrupted sleep pattern, hence, explaining an underlying mechanism behind healthy or unhealthy brain aging. The model incorporates accumulation and elimination of garbage, induction of glial activation by garbage, and glial senescence by over-activation, as well as the production of pro-inflammatory molecules by their senescence-associated secretory phenotype (SASP). Assuming that insufficient sleep leads to the increase of garbage concentration and promotes senescence, the model predicts that if the accumulation of senescent glia overcomes an inflammaging threshold, further progression of senescence becomes unstoppable even if a normal sleep pattern is restored. Inverting this process by "rejuvenating the brain" is only possible via a reset of concentration of senescent glia below this threshold. Our model approach enables analysis of space-time dynamics of senescence, and in this way, we show that heterogeneous patterns of inflammation will accelerate the propagation of senescence profile through a network, confirming a negative effect of heterogeneity

Comparative statistical study of two local clustering coefficient formulations as tropical cyclone markers for climate networks

We introduce a new formulation of local clustering coefficient for weighted correlation networks. This new formulation is based upon a definition introduced previously in the neuroscience context and aimed at compensating for spurious correlations caused by indirect interactions. We modify this definition further by replacing Pearson's pairwise correlation coefficients and three-way partial correlation coefficients by the respective Kendall's rank correlations. This reduces statistical sample size requirements to compute the correlations, which translates into the possibility of using shorter time windows and hence into a shorter response time of the real-time climate network analysis. We construct evolving climate networks of mean sea level pressure fluctuations and analyze anomalies of local clustering coefficient in these networks. We develop a broadly applicable statistical methodology to study association between spatially inhomogeneous georeferenced multivariate time series and binary-valued spatiotemporal data (or other data reducible to this representation) and use it to compare the newly proposed formulation of local clustering coefficient (for weighted correlation networks) to the conventional one (for unweighted graphs) in terms of the association of these measures in climate networks to tropical cyclones. Thus we substantiate the previously made observation that tropical cyclones are associated with anomalously high values of local clustering coefficient, and confirm that the new formulation shows a stronger association

The Human Body as a Super Network : Digital Methods to Analyze the Propagation of Aging

© 2020 Whitwell, Bacalini, Blyuss, Chen, Garagnani, Gordleeva, Jalan, Ivanchenko, Kanakov, Kustikova, Mariño, Meyerov, Ullner, Franceschi and Zaikin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY - https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Biological aging is a complex process involving multiple biological processes. These can be understood theoretically though considering them as individual networks—e.g., epigenetic networks, cell-cell networks (such as astroglial networks), and population genetics. Mathematical modeling allows the combination of such networks so that they may be studied in unison, to better understand how the so-called “seven pillars of aging” combine and to generate hypothesis for treating aging as a condition at relatively early biological ages. In this review, we consider how recent progression in mathematical modeling can be utilized to investigate aging, particularly in, but not exclusive to, the context of degenerative neuronal disease. We also consider how the latest techniques for generating biomarker models for disease prediction, such as longitudinal analysis and parenclitic analysis can be applied to as both biomarker platforms for aging, as well as to better understand the inescapable condition. This review is written by a highly diverse and multi-disciplinary team of scientists from across the globe and calls for greater collaboration between diverse fields of research.Peer reviewe

Stationary patterns in CNN-like ensembles with modified cell output functions

Stationary pattern formation in ensembles of coupled bistable elements is investigated both analytically and by means of numerical simulation. The models considered are similar to cellular nonlinear networks (CNNs) - a well-known class of collective dynamical systems intended mainly for image processing - but differ from them in the type of nonlinear functions contained in their equations of motion - cell output functions. The main subject of interest is the transformation of initial conditions, treated as a representation of a half-tone image, into a steady-state pattern. In the analytical part the location of attractors and their basins of attraction in the phase space are estimated for two types of CNN-like systems. In the simulation part the equations of two lattice systems - a CNN and a CNN-like system with local negative coupling are integrated numerically with initial conditions taken in the form of a sample halftone image. The dependence of the patterns established in both systems upon parameters is studied and compared. The present paper proves, that CNN-like systems with modified cell output functions may be studied analytically, and results available for conventional CNNs may be adapted to this wider class of lattice systems. From the application point of view, it is shown, that the modification of cell output functions under certain conditions does not lead to a breakdown of the system functionality. Moreover, an example is presented, where such a modification allows to introduce new functionality into a system (namely, controlling contour lines width in an edge-detecting system)

Training a distributed classifier with a linear target border.

<p>(A) Target classes: <i>P</i>—positive, <i>D</i>—negative. (B) Trained ensemble region on the plane of parameters: hatched area.</p